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Topiramate
(anti-seizure medications) Summary of Anti-seizure medications Some of the more effective and commonly used medications for chronic pain are drugs that were developed to control other conditions. Anti-seizure (anticonvulsant) medications were developed primarily to reduce or control epileptic seizures, but they also help control stabbing or shooting pain from nerve damage. These drugs seem to work by quieting damaged nerves to slow or prevent uncontrolled pain signals. These medications can cause dizziness, drowsiness, nausea and lack of balance and coordination. But most people are bothered only minimally. More severe but less common side effects include blood and liver disorders. To reduce your risk of side effects, your doctor will likely start you off on a small amount of the drug and gradually increase the dose while monitoring you.
Topiramate (brand name Topamax) is an drug produced by , a division of . It is used to treat in both children and adults. In children it is also indicated for treatment of (a disorder that causes seizures and developmental delays). It is also approved for, and now most frequently prescribed for, the prevention of . In May 2006 the U.S. National Institutes of Health web site clinicaltrials.gov listed several studies sponsored by Ortho-McNeil which propose to examine the use of topiramate on , , and severe headaches within various demographics. The most common side effects include a change in taste (carbonated beverages, especially diet sodas and beer, taste particularly bad) and feelings of pins and needles in the head and extremities. Less common side effects include cognitive deficiency (particularly word-finding difficulty); grogginess; lethargy; (kidney) stones, impairment of fine motor skills; vision abnormality and transient or permanent vision loss (see below for FDA warning); weight loss; breast pain; abdominal pain; intense sweating; menstrual disorder; taste changes; ; ; ; rash; ; fatigue; dizziness; insomnia; anxiety; depression; ; diarrhea; nausea; ; constipation; dry-mouth; . The side-effects most frequently leading to discontinuation of therapy with topiramate were : Psychomotor slowing (4.1%) Memory problems (3.3%) Fatigue (3.3%) Confusion (3.2%) Somnolence (3.2%) Food and Drug Administration has issued a notification alerting physicians who prescribe topiramate, and their patients, to the risk of vision loss (blindness). Acute |
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